Upton lies in an area well served by road and rail services, and is fortunate to have a local bus service.
First Great Western publish their timetables in PDF format.
The bus service No. 94, No longer a circular service, runs between Didcot, East Hagbourne, Blewbury, Upton, Chilton and Harwell Campus is operated by Thames Travel. The service now operates on a Saturday as well.
Sustrans details the cycle paths in the area.